Objective: To examine associations between hematological parameters ( hemoglobin, hematocrit, platelet (PLT(, red blood cell (RBC), and white blood cell (WBC)) and components of metabolic syndrome (MS) among the Syrian Coast population. Methods: Study subjects were 304 patients (140 men and 164 women), aged between 20-75 years, who attended endocrine and cardiac clinic in Tishreen and Al-Assad University Hospitals during the period from February 2015 to April 2016. MS was classified according to the International Diabetes Federation criterion. Odds ratios (OR) and 95% confidence intervals (95% CI) of MS were calculated using logistic regression procedures. Results: Hematologic parameters were significantly associated with MS components (Ptrend<0.05). and they increased with increasing number of MS components in both men and Women, All haematological parameters were positively associated with BMI, waist circumference, Triglycerides and negatively associated with HDL in male and female subjects. Among men, MS risk increased across successive quartiles of HB (OR= 4.43,9.27 and 10.18), HCT (OR= 3.57, 6 and 7.2), PLT (OR= 2.19, 4.18 and 20.86), WBC (OR= 1.59, 5.7 and 7.13) and RBC (OR= 4.49,5.32 and 9.68) as compared with those in the lowest reference group (P ≥ 0.0001). Among women, those in the highest quartiles of (HB, HCT, PLT , WBC and RBC) had respectively (1.26, 1.88, 10.93, 3.93 and 3.55)-fold increased odds of MetS as compared with those in the lowest reference group. Our findings provide further evidence in support of using hematological markers for early detection of individuals at risk for MS.