The aim of this study is to assess the spatial distribution of health centers in rural Lattakia governorate and to develop a scientific methodology to guide the growth of the health sector by identifying the needs and adequacy of the primary health care centers according to the spatial distribution of the population within these rural areas using spatial statistical techniques in GIS. In order to achieve this objective, a spatial database was created, including the population centers, the primary health care centers (health centers) with the population served by them, as well as a group of fields on the specifications of these centers in terms of ownership, floor space and human cadres. A number of quantitative and spatial tests were conducted in order to measure the fairness of the distribution of health centers according to the population distribution and determine the need, while attempting to find an initial guidance on the locations of the supporting centers according to quantitative and spatial analysis And then measure the degree of improvement according to the study indicators. The result of this research was to describe the current status of the distribution of health centers in the northern Latakia countryside, identify areas of weakness and inadequacy, propose supporting centers and develop an effective guideline for assessing and improving the placement of primary health care activities in rural areas.